Accurate diagnosis demands multimodal assessment.Â
Clinical examination:Â Physicians perform thorough physical checks palpating for abdominal massÂ
Imaging tests:Â Modalities visualize tumor anatomy and vascular involvement critical for staging through.
- UltrasoundÂ
- Contrast CT scanÂ
- MRI / MRCPÂ
- PET-CTÂ
- Endoscopic Ultrasound (EUS)
Laboratory tests:Â
Bloodwork guides suspicion with deranged liver function tests reflecting biliary stasis and elevated tumor markers like CA 19-9 over 37 U/mL correlating with burden though nonspecific in jaundice.
Biopsy:Â
Tissue confirmation is indicated in certain conditions and can be obtained safely byÂ
- EUS-guided biopsy samples core safely​
- CT-guided biopsy for body/tail lesions​
Advanced diagnostics:Â
Molecular profiling identifies BRCA for PARP inhibitors or MSI- status for immunotherapy, while staging investigations like laparoscopy rule out occult peritoneal disease.​